London draws people from all over the world. Some come on business, some come to study, to work or on holiday. London is naturally a very English city and it is very cosmopolitan, containing goods, food and entertainment, as well as people, from many countries of the world London stands on the river Thames. Crossing the river by the Tower Bridge you can see the Tower of London. It is one of the oldest buildings of the city. Many centuries ago it was a fortress, a royal palace and then a prison. Now it is a museum of arms.

The Tower of London. The Tower of London is one of the most interesting historic sights of London. The Tower was founded during the Norman Conquest of England sometimes at the end of 1066. It has 20 towers and the most important of all is the White Tower, which was built by William the Conqueror.

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On the bank of the Thames, not far from the Tower of London, you can see Westminster Palace, or the Houses of Parliament. It is the seat of the British government and it is one of the most beautiful buildings in London. In one of its towers there is famous Big Ben, the largest clock of England. It strikes every quarter of an hour. Westminster Palace.

Buckingham Palace is the Queen’s official London residence. Tourists always go to see the ceremony of changing the Guard there.

Background: Bleeding after percutaneous coronary interventions (PCI) is an important complication with impact on prognosis. Aim: To evaluate the predictive value of enhanced platelet responsiveness to dual antiplatelet therapy with aspirin and clopidogrel, for bleeding, after elective PCI. Method and results: We performed multiple electrode aggregometry (MAE) platelet functional tests induced by arachidonic acid (ASPI) and adenosine-diphosphate (ADP) before PCI, and 24 hours after PCI, in 481 elective PCI patients who were followed-up for an average of 15.34±7.19 months.

Primary end point was the occurrence of any bleeding, while ischemic major adverse cardiovascular event (MACE) was a secondary endpoint. The incidence of total, BARC≤2, and BARC≥3 bleeding, according to BARC classification, was 19%, 18% and 1%, respectively.

Groups with any, and BARC≤2 bleeding, had a lower average value of MAE ADP test after 24h, compared to the group without bleeding: 45.30±18.63 U vs. 50.99±19.01 U; p=0.005.

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